Evaluating the efficacy of a priming dose of cyclophosphamide prior to pembrolizumab to treat metastatic triple negative breast cancer.
Carey K AndersMark G WoodcockAmanda E D Van SwearingenDominic T MooreMaria J SambadeSonia LaurieAlexander RobesonOleg KolupaevLuz A CuaboyAmy L GarrettKaren McKinnonKristen CowensDante BortoneBenjamin C CalhounAlec D WilkinsonLisa CareyTrevor JollyHyman MussKatherine Reeder-HayesRebecca KaltmanRachel JankowitzVinay GudenaOludamilola OlajideCharles PerouE Claire DeesBenjamin G VincentJonathan S SerodyPublished in: Journal for immunotherapy of cancer (2022)
, and in those with decreased numbers there was rapid recovery following therapy. Increased B cell gene expression in baseline samples was associated with clinical response and IRT.