Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics.

Shannon R HinsonJosephe A HonoratEthan M GrundBenjamin D S ClarksonRamona MiskeMadeleine ScharfCecilia ZivelonghiMuhammad Taher Al-LoziRobert C BucelliAdrian BudhramTracey ChoEllie ChoiJacquelyn GrellAlfonso Sebastian Lopez-ChiribogaMarc LevinMelody MeratiMayra MontalvoSean J Pittock Michael R WilsonCharles L HoweAndrew McKeon

Published in: Annals of neurology (2022)

Septin-IgGs are predictive of distinct treatment-responsive autoimmune central nervous system (CNS) disorders. Live neuron binding and induced electrophysiologic effects by patient IgGs may support septin-specific pathophysiology. ANN NEUROL 2022;92:1090-1101.

Keyphrases

drug induced
high glucose
multiple sclerosis
case report
blood brain barrier
cancer therapy
combination therapy
endothelial cells
transcription factor
smoking cessation