Kinetics and 28-day test-retest repeatability and reproducibility of [11C]UCB-J PET brain imaging.
Hayel TuncelRonald BoellaardEmma M CoomansErik F J de VriesAndor W J M GlaudemansPaula Kopschina FeltesDavid Vállez GarcíaSander Cj VerfaillieEmma E WoltersSteven P SweeneyJ Michael RyanMagnus IvarssonBerkley A LynchPatrick SchoberPhilip ScheltensRobert C SchuitAlbert D WindhorstPeter P De DeynBart Nm van BerckelSandeep Sv GollaPublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2020)
[11C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was to determine the 28-day test-retest repeatability (TRT) of quantitative [11C]UCB-J brain positron emission tomography (PET) imaging in Alzheimer's disease (AD) patients and healthy controls (HCs). Nine HCs and eight AD patients underwent two 60 min dynamic [11C]UCB-J PET scans with arterial sampling with an interval of 28 days. The optimal tracer kinetic model was assessed using the Akaike criteria (AIC). Micro-/macro-parameters such as tracer delivery (K1) and volume of distribution (VT) were estimated using the optimal model. Data were also analysed for simplified reference tissue model (SRTM) with centrum semi-ovale (white matter) as reference region. Based on AIC, both 1T2k_VB and 2T4k_VB described the [11C]UCB-J kinetics equally well. Analysis showed that whole-brain grey matter TRT for VT, DVR and SRTM BPND were -2.2% ± 8.5, 0.4% ± 12.0 and -8.0% ± 10.2, averaged over all subjects. [11C]UCB-J kinetics can be well described by a 1T2k_VB model, and a 60 min scan duration was sufficient to obtain reliable estimates for both plasma input and reference tissue models. TRT for VT, DVR and BPND was <15% (1SD) averaged over all subjects and indicates adequate quantitative repeatability of [11C]UCB-J PET.
Keyphrases
- positron emission tomography
- pet imaging
- computed tomography
- white matter
- end stage renal disease
- ejection fraction
- pet ct
- chronic kidney disease
- newly diagnosed
- multiple sclerosis
- high resolution
- resting state
- patient reported outcomes
- machine learning
- photodynamic therapy
- functional connectivity
- magnetic resonance
- blood brain barrier
- patient reported