Evaluation of diffusion kurtosis and diffusivity from baseline staging MRI as predictive biomarkers for response to neoadjuvant chemoradiation in locally advanced rectal cancer.
David D B BatesYousef MazaheriStephanie LobaughJennifer S Golia PernickaViktoriya ParoderJinru ShiaJunting ZhengMarinela CapanuIva PetkovskaMarc J GollubPublished in: Abdominal radiology (New York) (2020)
Diffusivity shows promise as a potential imaging biomarker to predict AJCC TRG following neoadjuvant CRT, which has implications for risk stratification. Patients with TRG 0/1 have 5-year disease-free survival (DFS) of 90-98%, as opposed to those who are TRG 2/3 with 5-year DFS of 68-73%.
Keyphrases
- rectal cancer
- locally advanced
- free survival
- neoadjuvant chemotherapy
- diffusion weighted imaging
- phase ii study
- high resolution
- squamous cell carcinoma
- magnetic resonance imaging
- lymph node
- contrast enhanced
- radiation therapy
- pet ct
- cardiac resynchronization therapy
- big data
- machine learning
- magnetic resonance
- risk assessment
- climate change
- left ventricular
- heart failure
- artificial intelligence
- open label