Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy.
Xuanwen BaoHangyu ZhangWei WuShaobing ChengXiaomeng DaiXudong ZhuQihan FuZhou TongLulu LiuYi ZhengPeng ZhaoWeijia FangFanglong LiuPublished in: Journal for immunotherapy of cancer (2021)
Our analysis unraveled the difference in the molecular nature and genomic variance in MSI and MSS colon cancer. The microsatellite status-related gene signature is better at predicting the prognosis of patients with colon cancer and response to the combination of immune checkpoint inhibitor-based immunotherapy and anti-VEGF therapy.