Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.
Thássio Ricardo R MesquitaYen-Nien LinShuang ChenYoungho LeeRodrigo Miguel-Dos-SantosAsli E AticiMichael C FishbeinMagali Noval RivasMoshe ArditiEugenio CingolaniPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.
Keyphrases
- rheumatoid arthritis
- oxidative stress
- clinical trial
- cell wall
- diabetic rats
- high glucose
- left ventricular
- disease activity
- congenital heart disease
- drug induced
- stem cells
- ankylosing spondylitis
- heart failure
- mouse model
- systemic lupus erythematosus
- anti inflammatory
- bone marrow
- phase ii
- mesenchymal stem cells
- atrial fibrillation
- smoking cessation