Understanding genetic risk factors for common side effects of antidepressant medications.

Adrian I CamposAoibhe MulcahyJackson G ThorpNaomi R WrayEnda M ByrnePenelope A LindSarah E Medland Nicholas G MartinIan B HickieMiguel E Renteria

Published in: Communications medicine (2021)

Our results suggest a set of common factors underlying the risk for antidepressant side effects. These factors seem to be partly explained by genetic liability related to depression severity and the nature of the side effect. Future studies on the genetic aetiology of side effects will enable insights into their underlying mechanisms and the possibility of risk stratification and prophylaxis strategies.

Keyphrases

genome wide
major depressive disorder
copy number
gene expression
physical activity
bipolar disorder
sleep quality