Liquid chromatography-mass spectrometry-based metabolomics and fluxomics reveals the metabolic alterations in glioma U87MG multicellular tumor spheroids versus two-dimensional cell cultures.

Shanjing WenXinyi TuQingce ZangYing ZhuLimei LiRuiping ZhangZeper Abliz

Published in: Rapid communications in mass spectrometry : RCM (2023)

Our study highlights specific, altered biochemical pathways in MCTSs, emphasizing dysregulation of energy metabolism and lipid metabolism, and offering novel insight into metabolic events in glioma MCTSs.

Keyphrases

mass spectrometry
liquid chromatography
high resolution mass spectrometry
tandem mass spectrometry
gas chromatography
high performance liquid chromatography
capillary electrophoresis
single cell
high resolution
cell therapy
simultaneous determination
stem cells
mesenchymal stem cells