The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways.
Arshad Husain RahmaniAhmad Abdulaziz A AlmatroudiAmjad Ali KhanAli Yousif BabikerMalak AlaneziKhaled S AllemailemPublished in: Molecules (Basel, Switzerland) (2022)
The roles of medicinal plants or their purified bioactive compounds have attracted attention in the field of health sciences due to their low toxicity and minimal side effects. Baicalein is an active polyphenolic compound, isolated from Scutellaria baicalensis, and plays a significant role in the management of different diseases. Epidemiologic studies have proven that there is an inverse association between baicalein consumption and disease severity. Baicalein is known to display anticancer activity through the inhibition of inflammation and cell proliferation. Additionally, the anticancer potential of baicalein is chiefly mediated through the modulation of various cell-signaling pathways, such as the induction of apoptosis, autophagy, cell cycle arrest, inhibition of angiogenesis, signal transducer and activator of transcription 3, and PI3K/Akt pathways, as well as the regulation of other molecular targets. Therefore, the current review aimed to explore the role of baicalein in different types of cancer along with mechanisms of action. Besides this, the synergistic effects with other anti-cancerous drugs and the nano-formulation based delivery of baicalein have also been discussed.
Keyphrases
- risk assessment
- cell cycle arrest
- pi k akt
- human health
- signaling pathway
- cell death
- cell proliferation
- oxidative stress
- papillary thyroid
- single cell
- cell therapy
- healthcare
- public health
- endoplasmic reticulum stress
- stem cells
- squamous cell
- squamous cell carcinoma
- mental health
- endothelial cells
- mesenchymal stem cells
- vascular endothelial growth factor
- drug delivery
- inflammatory response
- drug induced
- health information
- cell cycle
- lymph node metastasis