Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.

David G CoughlinSharon X XieMendy LiangAndrew WilliamsClaire PetersonDaniel WeintraubCorey T McMillanDavid A WolkRizwan S AkhtarHoward I HurtigH Branch CoslettRoy H HamiltonAndrew D SiderowfJohn E DudaKatya RascovskyEdward B LeeVirginia M-Y LeeMurray GrossmanJohn Q TrojanowskiDavid John Irwin

Published in: Annals of neurology (2019)

LBD patients with AD copathology harbor greater neocortical SYN pathology. Regional tau pathology relates to cognitive performance in LBD dementia, and its distribution may diverge from pure AD. Tau copathology contributes uniquely to the heterogeneity of cognitive impairment in LBD. Ann Neurol 2018; 1-13 ANN NEUROL 2019;85:259-271.

Keyphrases

cognitive impairment
cerebrospinal fluid
neural network
single cell
parkinson disease
deep brain stimulation