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Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD.

Natasha A WinterPeter G GibsonVanessa Marie McDonaldMichael Fricker
Published in: International journal of chronic obstructive pulmonary disease (2021)
We demonstrate associations of MCs and basophils with eosinophilic inflammation and lower lung function in COPD. These findings are consistent with prior results in asthma and may represent a new tool for endotyping eosinophilic-COPD.
Keyphrases
  • lung function
  • cystic fibrosis
  • chronic obstructive pulmonary disease
  • gene expression
  • air pollution
  • chronic rhinosinusitis
  • oxidative stress
  • dna methylation