Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice.

Tzyy-Nan HuangTzu-Li YenLily R QiuHsiu-Chun ChuangJason P LerchYi-Ping Hsueh

Published in: Molecular autism (2019)

Tbr1 regulates neural circuits and activity in the olfactory system to control olfaction. Tbr1 +/- mice can serve as a suitable model for revealing how an autism causative gene controls neuronal circuits, neural activity, and autism-related behaviors.

Keyphrases

autism spectrum disorder
intellectual disability
high fat diet induced
copy number
genome wide
genome wide identification
cerebral ischemia
dna methylation
brain injury
adipose tissue
transcription factor
blood brain barrier
drug induced