Adverse effect of PNPLA3 p.I148M genetic variant on kidney function in middle-aged individuals with metabolic dysfunction.

Alessandro MantovaniSerena PelusiSara MargaritaFrancesco MalvestitiMichela Dell'AlmaCristiana BiancoLuisa RonzoniDaniele PratiGiovanni Targher Luca Vittorio Valenti

Published in: Alimentary pharmacology & therapeutics (2023)

levels in middle-aged individuals with metabolic dysfunction. This association was independent of established risk factors, ethnicity and genetic predisposition to CKD. PNPLA3 p.I148M silencing may protect against kidney damage progression in carriers.

Keyphrases

middle aged
risk factors
oxidative stress
genome wide
chronic kidney disease
copy number
emergency department
gene expression