Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study.

Tiago Reis MarquesMattia VeroneseDavid R OwenEugenii A RabinerGraham E SearleOliver D Howes

Published in: European journal of nuclear medicine and molecular imaging (2021)

In schizophrenia patients, a substantial component of the [11C]PBR28 signal represents specific binding to TSPO. Furthermore, the VND in patients with schizophrenia is similar to that previously reported in healthy controls. These results suggest that changes in non-specific binding between schizophrenia patients and healthy controls do not account for discrepant PET findings in this disorder.

Keyphrases

end stage renal disease
bipolar disorder
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
positron emission tomography
transcription factor
protein protein