Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis.
Delphine SterlinMartin LarsenJehane FadlallahChristophe ParizotMarina VignesGaëlle AutaaKarim DorghamCatherine JustePatricia LepageJennifer AboabSavine VicartElisabeth MaillartOlivier GoutCatherine LubetzkiRomain DeschampsCaroline PapeixGuy GorochovPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
Gut and systemic microbiota/immune homeostasis are perturbed in MS. Our results argue that defective IgA responses in MS are linked to a breakdown of systemic tolerance to gut microbiota leading to an enhanced triggering of systemic IgG immunity against gut commensals occurring early in MS.