Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients.
Avi GadothSean J PittockDivyanshu DubeyAndrew McKeonJeff W BrittonJohn E SchmelingAurelia SmithAmy L KotsenasRobert E WatsonDaniel H LachanceEoin P FlanaganVanda A LennonChristopher J KleinPublished in: Annals of neurology (2017)
Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. Response to initial immunotherapy is often favorable, but some patients remain severely disabled, requiring long-term immunotherapy and/or antiepileptic medications. Ann Neurol 2017;82:79-92.