MH-76, a Novel Non-Quinazoline α1-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats.
Monika KubackaSzczepan MogilskiMonika ZadrożnaBarbara NowakMałgorzata SzafarzBartosz PomiernyHenryk MaronaAnna M WaszkielewiczWojciech JawieńJacek SapaMarek BednarskiJoanna KnutelskaMagdalena KotańskaPublished in: Pharmaceuticals (Basel, Switzerland) (2021)
MH-76 may improve insulin signaling in adipose tissue by reducing the pro-inflammatory cytokine production and inhibiting the inflammatory cells recruitment. In contrast, in adipose tissue from animals treated with prazosin, the inflammatory effect was clearly enhanced.