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PD-1 mediates microglia polarization via the MAPK signaling pathway to protect blood-brain barrier function during cerebral ischemia/reperfusion.

Linqiang HuangXinping LiZhuo LiHuishan ZhuYongli HanJuhao ZengMiaoyun WenHongke Zeng
Published in: Brain research bulletin (2024)
Our present study verified that PD-1 exerts an anti-inflammatory effect by converting the microglia M1 phenotype to the M2 phenotype, reducing BBB permeability, and thereby relieves brain injury caused by cerebral ischemia. PD-1 is potential therapeutic target for brain injury caused by cerebral ischemia.
Keyphrases
  • cerebral ischemia
  • brain injury
  • blood brain barrier
  • subarachnoid hemorrhage
  • signaling pathway
  • anti inflammatory
  • inflammatory response
  • pi k akt
  • neuropathic pain
  • oxidative stress
  • risk assessment
  • spinal cord