Epithelial-mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease.
Mohit Kumar JollyChris WardMathew Suji EapenStephen MyersOskar HallgrenHerbert LevineSukhwinder Singh SohalPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)
Epithelial-mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346-358, 2018. © 2017 Wiley Periodicals, Inc.
Keyphrases
- epithelial mesenchymal transition
- extracellular matrix
- idiopathic pulmonary fibrosis
- chronic obstructive pulmonary disease
- transforming growth factor
- induced apoptosis
- signaling pathway
- lung function
- cell cycle arrest
- pulmonary fibrosis
- stem cells
- oxidative stress
- interstitial lung disease
- cell death
- bone marrow
- endoplasmic reticulum stress
- pi k akt
- case report
- cell proliferation
- air pollution
- cystic fibrosis
- respiratory syncytial virus