Pea (Pisum sativum) allergy in children: Pis s 1 is an immunodominant major pea allergen and presents IgE binding sites with potential diagnostic value.

Jasmin PoppValérie TrendelenburgBodo NiggemannStefanie RandowElke VölkerLothar VogelAndreas ReuterJelena SpiricDirk SchillerKirsten BeyerThomas Holzhauser

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

In this study group, Pis s 1 is a major immunodominant allergen in pea-allergic children. Evidence for sensitization to nsLTP and 2S albumins was low but requires further verification with regard to conformational epitopes. Recombinant Pis s 1 and related peptides which were exclusively recognized by pea-allergic children may improve in vitro diagnosis of pea allergy once verified in prospective studies with larger study groups.

Keyphrases

young adults
atopic dermatitis
molecular dynamics
risk assessment
climate change
infectious diseases
case control
drug induced