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Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

Maria Lukács KrogagerRegitze Kuhr SkalsEmil Vincent R AppelTheresia M SchnurrLine EngelbrechtsenChristian Theil HaveOluf PedersenThomas EngstrømDan M RodenGunnar GislasonHenrik Enghusen PoulsenLars KøberSteen StenderTorben HansenNiels GrarupCharlotte AnderssonChristian Torp-PedersenPeter E Weeke
Published in: PloS one (2018)
Hypertension GRS quartiles were associated with an increased risk of hypertension, prevalent CHD, and burden of coronary vessel disease in a dose-response pattern. We showed no evidence for pleiotropy with other risk factors for CHD.
Keyphrases
  • blood pressure
  • coronary artery
  • coronary artery disease
  • heart failure
  • arterial hypertension
  • gene expression
  • left ventricular