Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

Maria Lukács KrogagerRegitze Kuhr SkalsEmil Vincent R AppelTheresia M SchnurrLine EngelbrechtsenChristian Theil HaveOluf PedersenThomas EngstrømDan M RodenGunnar GislasonHenrik Enghusen PoulsenLars KøberSteen StenderTorben HansenNiels GrarupCharlotte AnderssonChristian Torp-PedersenPeter E Weeke

Published in: PloS one (2018)

Hypertension GRS quartiles were associated with an increased risk of hypertension, prevalent CHD, and burden of coronary vessel disease in a dose-response pattern. We showed no evidence for pleiotropy with other risk factors for CHD.

Keyphrases

blood pressure
coronary artery
coronary artery disease
heart failure
arterial hypertension
gene expression
left ventricular