The rs7044343 Polymorphism of the Interleukin 33 Gene Is Associated with Decreased Risk of Developing Premature Coronary Artery Disease and Central Obesity, and Could Be Involved in Regulating the Production of IL-33.

Javier Angeles-MartínezRosalinda Posadas-SánchezLuis LlorenteEdith Alvarez-LeónJulian Ramírez-BelloTeresa Villarreal-MolinaGuadalupe LimaGuillermo Cardoso-SaldañaJosé Manuel Rodríguez-PérezNonanzit Pérez-HernándezJosé Manuel FragosoCarlos Posadas-RomeroGilberto Vargas-Alarcon

Published in: PloS one (2017)

The results suggest that the IL-33 rs7044343 T allele could be a susceptibility marker for premature CAD and central obesity. The rs7044343 polymorphism could be involved in regulating the production of IL-33.

Keyphrases

coronary artery disease
insulin resistance
metabolic syndrome
weight loss
type diabetes
high fat diet induced
percutaneous coronary intervention
cardiovascular events
genome wide
cardiovascular disease
gene expression
adipose tissue
skeletal muscle
body mass index
dna methylation
transcription factor
aortic valve