Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Shiyou WeiDelong YinShengnan YuXiang LinMilan R SavaniKuang DuYin KuDi WuShasha LiHao LiuMeng TianYaohui ChenMichelle BowieSeethalakshmi HariharanMatthew S WaitkusStephen T KeirEric T SugarmanRebecca A DeekMarilyne LabrieMustafa KhasrawYiling LuGordon B MillsMeenhard HerlynKongming WuLun-Xu LiuZhi WeiKeith T FlahertyKalil G AbdullahGao ZhangDavid M AshleyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These preclinical findings established the therapeutic role of Gamitrinib in gliomas and revealed the inhibition of mitochondrial biogenesis and tumor bioenergetics as the primary antitumor mechanisms in gliomas.