Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury.
Sebastian BilligMarc HeinCeline KirchnerDavid SchumacherMoriz Aljoscha HabigtMare MechelinckDieter FuchsUwe KlingeAlexander TheißenChristian BeckersChristian BleilevensRafael KramannMoritz UhligPublished in: Biomedicines (2024)
In summary, acute cholestasis-induced liver injury can lead to impaired cardiac function mediated by coronary microvascular dysfunction, suggesting that major adverse cardiac events may contribute to the mortality of acute liver failure. This may be due to endothelial dysfunction and direct bile acid signaling.
Keyphrases
- liver failure
- hepatitis b virus
- drug induced
- coronary artery disease
- coronary artery
- respiratory failure
- oxidative stress
- type diabetes
- left ventricular
- aortic dissection
- risk factors
- cardiovascular disease
- heart failure
- aortic valve
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation