Rheumatoid arthritis is a protective factor against Alzheimer's disease: a bidirectional two-sample Mendelian randomization study.

Guo-Shuai LiYong-Ze YangGuo-Rong MaPeng-Fei LiQing-Hao ChengAn-Ren ZhangZhuang-Zhuang ZhangFu-Kang ZhangXin YangHua FanHong-Zhang Guo

Published in: Inflammopharmacology (2023)

The results of this two-way two-sample Mendelian randomization analysis revealed a causal association between genetic susceptibility to RA and a reduced risk of AD but did not reveal a causal association between genetic susceptibility to AD and an increased or reduced risk of RA.

Keyphrases

rheumatoid arthritis
genome wide
disease activity
ankylosing spondylitis
single cell
interstitial lung disease
copy number
cognitive decline
mild cognitive impairment
idiopathic pulmonary fibrosis