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Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools.

Simone CarronGabi DezsiEzgi OzturkJess NithianantharajahNigel Charles Jones
Published in: Epilepsia (2019)
Using translationally relevant behavioral tools in combination with traditional assays to measure cognition in animal models, here we identify impairments in learning and memory, and enhanced perseverative behaviors in rats with epilepsy. These tools can be used in future research to explore biologic mechanisms and treatments for cognitive deficits associated with epilepsy.
Keyphrases
  • temporal lobe epilepsy
  • rheumatoid arthritis
  • high throughput
  • mild cognitive impairment
  • white matter