Effects of hydroxyurea on brain function in children with sickle cell anemia.

Winfred C WangPing ZouScott N HwangGuolian KangJuan DingAndrew M HeitzerJane E SchreiberKathleen HeltonJane Silva Hankins

Published in: Pediatric blood & cancer (2021)

Improvements in neurocognition and decreased TCD velocity following 1 year of treatment support hydroxyurea use for improving neurocognitive outcomes in SCA. Understanding the mechanisms of benefit, as indicated by relationships of neurocognitive function with HbF, hemoglobin, and CBF, requires further evaluation.

Keyphrases

sickle cell disease
bipolar disorder
young adults
chronic kidney disease
white matter
resting state
multiple sclerosis
weight loss
subarachnoid hemorrhage