Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

Mrinal K SarkarGrace A HileLam C TsoiXianying XingJianhua LiuYun LiangCeline C BerthierWilliam R SwindellMatthew T PatrickShuai ShaoPei-Suen TsouRanjitha UppalaMaria A BeamerAnshika SrivastavaStephanie L BielasPaul W HarmsSpiro GetsiosJames T ElderJohn J VoorheesJohann E GudjonssonJ Michelle Kahlenberg

Published in: Annals of the rheumatic diseases (2018)

Collectively, our data identify IFN-κ as a critical IFN in CLE pathology via promotion of enhanced IFN responses and photosensitivity. IFN-κ is a potential novel target for UVB prophylaxis and CLE-directed therapy.

Keyphrases

dendritic cells
immune response
systemic lupus erythematosus
electronic health record
nuclear factor
rheumatoid arthritis
machine learning
mesenchymal stem cells
stem cells
disease activity
replacement therapy