Oligosaccharides from black ginseng innovatively prepared by low-temperature steam-heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap-1/Nrf2 pathway.
Weiyin XuPeng YuSimeng ShaoZhaoyang XieYi WuJianing LiuTianyang XuGuangzhi CaiHongmei YangPublished in: Journal of the science of food and agriculture (2024)
Our results showed for the first time a clear role for OSBG in improving scopolamine-induced memory impairment by inhibiting cholinergic dysfunction in a tissue-dependent manner. Additionally, OSBG administration relieved oxidative stress by activating the Keap-1/Nrf2 pathway and modulating the gut microbiota. Collectively, OSBG may be a promising target for neuroprotective antioxidants for improving memory and cognition in Alzheimer's disease patients. © 2024 Society of Chemical Industry.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- end stage renal disease
- cognitive impairment
- chronic kidney disease
- cognitive decline
- ejection fraction
- working memory
- dna damage
- peritoneal dialysis
- ischemia reperfusion injury
- induced apoptosis
- prognostic factors
- protein protein
- patient reported outcomes
- metabolic syndrome
- subarachnoid hemorrhage