Differential impact of individual autonomic domains on clinical outcomes in Parkinson's disease.

Katherine LongardnerAristide MerolaIrene LitvanAlberto Maria De StefanoSimona MauleFabrizio VallelongaLeonardo LopianoAlberto Romagnolo

Published in: Journal of neurology (2022)

Cardiovascular dysautonomia, but not other domains, showed an association with worse 5-year clinical outcomes in PD. Our data suggest a specific role for cardiovascular autonomic dysregulation in the pathogenic mechanisms of PD progression.

Keyphrases

heart rate variability
heart rate
electronic health record
big data
machine learning
artificial intelligence
deep learning