Photobiomodulation mitigates Bothrops jararacussu venom-induced damage in myoblast cells by enhancing myogenic factors and reducing cytokine production.

Luciana Miato Gonçalves SilvaViviane Almeida GouveiaGabriela Russo Soeiro CamposCamila Squarzone DaleRenata Kelly da PalmaAna Paula Ligeiro de OliveiraRodrigo Labat MarcosCinthya Cosme Gutierrez DuranJosé Carlos CogoJosé Antônio Silva JuniorStella Regina Zamuner

Published in: PLoS neglected tropical diseases (2024)

These data demonstrated that protection of the muscle cell by PBM seems to be related to the increase of myogenic factors as well as the modulation of inflammatory mediators. PBM therapy may offer a new therapeutic strategy to address the local effects of snakebite envenoming by promoting muscle regeneration and reducing the inflammatory process.

Keyphrases

skeletal muscle
oxidative stress
induced apoptosis
diabetic rats
stem cells
cell therapy
single cell
cell cycle arrest
high glucose
wound healing
electronic health record
drug induced
big data
cell death
machine learning
endoplasmic reticulum stress
mesenchymal stem cells
cell proliferation
data analysis