Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort.
Kui DengMenglei ShuaiZheqing ZhangZengliang JiangYuanqing FuLuqi ShenJu-Sheng ZhengYu-Ming ChenPublished in: BMC medicine (2022)
Our study identified one potentially beneficial microbe Lachnospiraceae bacterium 3 1 57FAA CT1, which might mediate the effect of adiposity on insulin resistance. The identified microbes are helpful for the discovery of novel therapeutic targets, as to mitigate the impact of adiposity on insulin resistance.
Keyphrases
- insulin resistance
- adipose tissue
- high fat diet
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- high fat diet induced
- endothelial cells
- small molecule
- computed tomography
- glycemic control
- induced pluripotent stem cells
- magnetic resonance imaging
- positron emission tomography
- dual energy
- weight gain
- physical activity