Obesity predisposes to the risk of higher mortality in young COVID-19 patients.
Fengqin ZhangYing XiongYanqiu WeiYi HuFeng WangGang LiKui LiuRonghui DuCong-Yi WangWenzhen ZhuPublished in: Journal of medical virology (2020)
Although emerging data demonstrated mortality of young COVID-19 patients, no data have reported the risk factors of mortality for these young patients, and whether obesity is a risk for young COVID-19 patients remains unknown. We conducted a retrospective study including 13 young patients who died of COVID-19 and 40 matched survivors. Logistic regression was employed to characterize the risk factors of mortality in young obese COVID-19 patients. Most of the young deceased COVID-19 patients were mild cases at the time of admission, but the disease progressed rapidly featured by a higher severity of patchy shadows (100.00% vs 48.70%; P = .006), pleural thickening (61.50% vs 12.80%; P = .012), and mild pericardial effusion (76.90% vs 0.00%; P < .001). Most importantly, the deceased patients manifested higher body mass index (odds ratio [OR] = 1.354; 95% confidence interval [CI] = 1.075-1.704; P = .010), inflammation-related index C-reactive protein (OR = 1.014; 95% CI = 1.003-1.025; P = .014), cardiac injury biomarker hs-cTnI (OR = 1.420; 95% CI = 1.112-1.814; P = .005), and increased coagulation activity biomarker D-dimer (OR = 418.7; P = .047), as compared with that of survivors. Our data support that obesity could be a risk factor associated with high mortality in young COVID-19 patients, whereas aggravated inflammatory response, enhanced cardiac injury, and increased coagulation activity are likely to be the mechanisms contributing to the high mortality.
Keyphrases
- risk factors
- sars cov
- cardiovascular events
- middle aged
- metabolic syndrome
- body mass index
- weight loss
- type diabetes
- inflammatory response
- end stage renal disease
- insulin resistance
- ejection fraction
- weight gain
- chronic kidney disease
- newly diagnosed
- oxidative stress
- coronavirus disease
- left ventricular
- heart failure
- high fat diet induced
- toll like receptor
- coronary artery disease
- physical activity
- machine learning
- skeletal muscle
- lps induced
- artificial intelligence
- deep learning