CDC7 as a novel biomarker and druggable target in cancer.
Runze LiuLiping ZhongPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)
Due to the bottlenecks encountered in traditional treatment for tumor, more effective drug targets need to be developed. Cell division cycle 7 kinase plays an important role in DNA replication, DNA repair and recombination signaling pathways. In this review, we first describe recent studies on the role of CDC7 in DNA replication in normal human tissues, and then we integrate new evidence focusing on the important role of CDC7 in replication stress tolerance of tumor cells and its impact on the prognosis of clinical oncology patients. Finally, we comb through the CDC7 inhibitors identified in recent studies as a reference for further research in clinical practice.
Keyphrases
- dna repair
- cell cycle
- dna damage
- clinical practice
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- signaling pathway
- chronic kidney disease
- dna damage response
- prognostic factors
- gene expression
- single cell
- papillary thyroid
- palliative care
- emergency department
- case control
- squamous cell carcinoma
- cell therapy
- cell proliferation
- stem cells
- oxidative stress
- lymph node metastasis
- drug induced
- adverse drug
- electronic health record
- mesenchymal stem cells