Redox-Annulations of Cyclic Amines with Electron-Deficient o-Tolualdehydes.
Anirudra PaulAlafate AdiliDaniel SeidelPublished in: Organic letters (2019)
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-methyl-3,5-dinitrobenzaldehyde and closely related substrates. Acetic acid serves as the solvent and sole promoter of these transformations which involve dual C-H functionalization.