Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation.
Hwa-Sun LeeDineth Pramuditha NagahawattaYung Hyun ChoiMin Ah LeeChang-Su HeoSun Joo ParkHee Jae ShinPublished in: Marine drugs (2023)
Inflammatory diseases caused by air pollution, especially from particulate matter (PM) exposure, have increased daily. Accordingly, attention to treatment or prevention for these inflammatory diseases has grown. Natural products have been recognized as promising sources of cures and prevention for not only inflammatory but also diverse illnesses. As part of our ongoing study to discover bioactive compounds from marine microorganisms, we isolated streptinone, a new indanone derivative ( 1 ), along with three known diketopiperazines ( 2 - 4 ) and piericidin A ( 5 ), from a marine sediment-derived Streptomyces massiliensis by chromatographic methods. The structure of 1 was elucidated based on the spectroscopic data analysis. The relative and absolute configurations of 1 were determined by 1 H- 1 H coupling constants, 1D NOESY, and ECD calculation. The anti-inflammatory activities of 1 were evaluated through enzyme-linked immunosorbent assay (ELISA), Western blot, and qPCR. Compound 1 suppressed the production of nitric oxide (NO), prostaglandin E 2 (PGE 2 ), and pro-inflammatory cytokines such as TNF- α , IL-6, and IL-1 β , by inhibiting the Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF- κ B) signaling pathway. Therefore, compound 1 could potentially be used as an agent in the prevention and treatment of diverse inflammatory disorders caused by particulate matter.
Keyphrases
- particulate matter
- nuclear factor
- toll like receptor
- air pollution
- oxidative stress
- signaling pathway
- inflammatory response
- nitric oxide
- data analysis
- anti inflammatory
- immune response
- lung function
- diabetic rats
- lps induced
- rheumatoid arthritis
- molecular docking
- physical activity
- cystic fibrosis
- high throughput
- pi k akt
- working memory
- molecular dynamics simulations
- epithelial mesenchymal transition
- high glucose
- nitric oxide synthase
- water soluble
- chronic obstructive pulmonary disease
- risk assessment
- replacement therapy
- hydrogen peroxide
- stress induced
- room temperature
- cell proliferation