Flavin catalyzed desulfurization of peptides and proteins in aqueous media.
Chuan WanDongyan YangXuan QinZiyi XueXiaochun GuoZhanfeng HouChenran JiangFeng YinRui WangZigang LiPublished in: Organic & biomolecular chemistry (2022)
A biomimetic method has been established for the chemo-selective desulfurization of cysteinyl peptides and proteins in aqueous media. The derivatives of biocatalytic cofactors, flavins, were found to be efficient photosensitizers in a thiyl-radical-mediated desulfurization of Cys. The reaction was conducted in an ultrafast manner with both polypeptides and proteins.