Mesenchymal stem cells derived from human dental follicle modulate the aberrant immune response in atopic dermatitis.
Noushin ZibandehDeniz GencZuleyha OzgenYazgul DuranKamil GokerSafa BarışTulin ErgunTunç AkkoçPublished in: Immunotherapy (2021)
Background: Atopic dermatitis (AD) is an inflammatory cutaneous disorder. The advancements in the understanding of AD immunological pathogenesis have caused the development of therapies that suppress the dysregulated immune response. We aimed to evaluate the immunomodulatory effect of dental stem cells (dental follicle-mesenchymal stem cells [DF-MSCs]) on AD patients. Materials & methods: We investigated the immunoregulatory potential of DF-MSCs on T cell response in AD and compared them with psoriasis and healthy individuals and the underlying mechanisms. Results: DF-MSCs significantly reduced Fas, FasL and TNFR II frequency in T cells, increased naive T cell population while reducing memory T cell, decreased inflammatory cytokine levels and promoted Tregs frequency in the AD population. Conclusion: These results imply that DF-MSCs are modulating inflammation through decreasing T cell apoptosis, inducing Treg expansion and stabilizing cytokine levels.
Keyphrases
- mesenchymal stem cells
- atopic dermatitis
- umbilical cord
- immune response
- stem cells
- oxidative stress
- bone marrow
- cell therapy
- oral health
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- signaling pathway
- prognostic factors
- hiv infected
- toll like receptor
- working memory
- human health
- risk assessment
- atomic force microscopy
- climate change
- high speed
- single molecule