Mechanism and Role of Endoplasmic Reticulum Stress in Osteosarcoma.
Peijun ZhuTing LiQingqing LiYawen GuYuan ShuKaibo HuLeifeng ChenXiaogang PengJie PengLiang HaoPublished in: Biomolecules (2022)
Osteosarcoma is the most common malignant bone tumor, often occurring in children and adolescents. The etiology of most patients is unclear, and the current conventional treatment methods are chemotherapy, radiotherapy, and surgical resection. However, the sensitivity of osteosarcoma to radiotherapy and chemotherapy is low, and the prognosis is poor. The development of new and useful treatment strategies for improving patient survival is an urgent need. It has been found that endoplasmic reticulum (ER) stress (ERS) affects tumor angiogenesis, invasion, etc. By summarizing the literature related to osteosarcoma and ERS, we found that the unfolded protein response (UPR) pathway activated by ERS has a regulatory role in osteosarcoma proliferation, apoptosis, and chemoresistance. In osteosarcoma, the UPR pathway plays an important role by crosstalk with autophagy, oxidative stress, and other pathways. Overall, this article focuses on the relationship between ERS and osteosarcoma and reviews the potential of drugs or gene targets associated with ERS for the treatment of osteosarcoma.
Keyphrases
- endoplasmic reticulum stress
- oxidative stress
- induced apoptosis
- endoplasmic reticulum
- locally advanced
- early stage
- end stage renal disease
- cell death
- radiation therapy
- chronic kidney disease
- squamous cell carcinoma
- ejection fraction
- transcription factor
- endothelial cells
- dna damage
- newly diagnosed
- risk assessment
- dna methylation
- small molecule
- gene expression
- radiation induced
- smoking cessation
- amino acid
- body composition
- ischemia reperfusion injury
- protein protein
- diabetic rats
- cell migration
- patient reported outcomes
- binding protein