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Transfer of Cardiac Mitochondria Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in a Preclinical Model of Ischemic Heart Disease.

Marie Luce VignaisJennyfer LevouxPierre SicardKhattar KhattarCatherine LozzaMarianne GervaisSafia MezhoudJean NakhleFrederic RelaixOnnik AgbulutJeremy FauconnierAnne-Marie Rodriguez
Published in: Cells (2023)
The preconditioning of MSCs with the artificial transfer of cardiac mitochondria appears to be promising strategy to improve the efficacy of MSC-based cell therapy in ischemic heart disease.
Keyphrases
  • cell therapy
  • mesenchymal stem cells
  • umbilical cord
  • left ventricular
  • stem cells
  • cell death
  • bone marrow
  • reactive oxygen species
  • endoplasmic reticulum
  • heart failure
  • oxidative stress
  • blood brain barrier