Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection.
Roberto CarnevaleVittoria CammisottoSimona BartimocciaCristina NocellaValentina CastellaniMarianna BufanoLorenzo LoffredoSebastiano SciarrettaGiacomo FratiAntonio ColucciaRomano SilvestriGiancarlo CeccarelliAlessandra OlivaMario VendittiFrancesco PuglieseClaudio Maria MastroianniOmbretta TurrizianiMartina LeopizziGiulia D'AmatiPasquale PignatelliFrancesco VioliPublished in: Circulation research (2023)
The study identifies 2 TLR4-dependent and independent pathways promoting platelet-dependent thrombus growth and suggests inhibition of TLR4. or p47phox as a tool to counteract thrombosis in SARS-CoV-2.