Retracted Article: Synthesis of deuterated isopentyl pyrophosphates for chemo-enzymatic labelling methods: GC-EI-MS based 1,2-hydride shift in epicedrol biosynthesis.
Madhukar S SaidGovinda R NavaleJayant M GajbhiyeSandip S ShindePublished in: RSC advances (2019)
A sesquiterpene epicedrol cyclase mechanism was elucidated based on the gas chromatography coupled to electron impact mass spectrometry fragmentation data of deuterated ( 2 H) epicedrol analogues. The chemo-enzymatic method was applied for the specific synthesis of 8-position labelled farnesyl pyrophosphate and epicedrol. EI-MS fragmentation ions compared with non-labelled and isotopic mass shift fragments suggest that the 2 H of C6 migrates to the C7 position during the cyclization mechanism.
Keyphrases
- mass spectrometry
- gas chromatography
- liquid chromatography
- high resolution mass spectrometry
- photodynamic therapy
- hydrogen peroxide
- gas chromatography mass spectrometry
- high performance liquid chromatography
- capillary electrophoresis
- tandem mass spectrometry
- high resolution
- cancer therapy
- locally advanced
- combination therapy
- electronic health record
- multiple sclerosis
- quantum dots
- big data
- drug delivery
- molecular docking
- squamous cell carcinoma
- radiation therapy
- data analysis
- nitric oxide
- solid phase extraction
- rectal cancer
- artificial intelligence
- deep learning