Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis.

Latha VelayudhanKatie McGoohanSagnik Bhattacharyya

Published in: PLoS medicine (2021)

This pooled analysis, using data from RCTs with mean participant age ≥50 years, suggests that although THC-containing CBMs are associated with side effects, CBMs in general are safe and acceptable in older adults. However, THC:CBD combinations may be less acceptable in the dose ranges used and their tolerability may be different in adults over 65 or 75 years of age.

Keyphrases

open label
physical activity
double blind
electronic health record
placebo controlled
big data
data analysis