Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells.

Sebastiano Di BucchianicoAnda R GligaEmma ÅkerlundSara SkoglundInger Odnevall WallinderBengt FadeelHanna L Karlsson

Published in: Particle and fibre toxicology (2018)

This study has revealed chromosomal damage by Ni and NiO NPs as well as Ni ionic species and provides novel evidence for a calcium-dependent mechanism of cyto- and genotoxicity.

Keyphrases

oxide nanoparticles
induced apoptosis
oxidative stress
cell cycle arrest
metal organic framework
single cell
ionic liquid
copy number
gene expression
endoplasmic reticulum stress
cell death
genome wide
genetic diversity