Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups.

Heba AlshakerRobert MillsEwan HunterMatthew SalterAroul RamadassBenjamin Matthew SkinnerWillem WestraJayne GreenAlexandre AkoulitchevMathias WinklerDmitri Pchejetski

Published in: Journal of translational medicine (2021)

Our results demonstrate specific chromosome conformations in the blood of PCa patients that allow PCa diagnosis and risk stratification with high sensitivity and specificity.

Keyphrases

prostate cancer
peripheral blood
end stage renal disease
chronic kidney disease
ejection fraction
gene expression
dna damage
prognostic factors
radical prostatectomy
transcription factor
genome wide
dna methylation
copy number