Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.

Joseph W Meisel Chunhua Tony HuAndrew D Hamilton

Published in: Organic letters (2018)

The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.

Keyphrases

fluorescent probe
living cells
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molecular dynamics simulations
tissue engineering
energy transfer
quantum dots
computed tomography