Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal Dialysate.

Saran Lotfollahzadeh Aniket Vazirani Isaac E Sellinger Janelle Clovie Isaac Hoekstra Arjun PatelAbbas Brahim MalloumWenqing Yin Herreet Paul Pranav YadatiJeffrey SiracusMarina MalikovaLuise I PernarJean FrancisLauren D Stern Vipul C Chitalia

Published in: Kidney360 (2024)

This study uncovers the activation of the AHR-cytokine axis in the endothelial cells of subperitoneal vessels in humans and mice with CKD, which is likely to prime the peritoneal membrane to peritoneal dialysate-mediated alterations. This study supports further exploration of AHR as a potential therapeutic target to preserve the structural and functional integrity of the peritoneal membrane in peritoneal dialysis.

Keyphrases

peritoneal dialysis
end stage renal disease
chronic kidney disease
endothelial cells
skeletal muscle
vascular endothelial growth factor
high fat diet induced
wild type