PKC-delta and PKD activate MAPK signal pathway in mechano-transcription of colonic smooth muscle cells.
Zhaoyun YangKang HeTaiwei WangYan GaoMengmeng ChenKai WangZeyu WangHao WuShuang ZhangLijing ZhaoPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2023)
Mechanical stretch induces phosphorylation of PKCs and PKD in the colonic SMCs. PKC-delta and PKD are involved in the activation of MAPKs and induction of COX-2 in response to mechanical stretch. Inhibition of mechano-transcription has beneficial effects on motility dysfunction in bowel obstruction.