Treatment Strategy for Rifampin-Susceptible Tuberculosis.
Nicholas Iain PatonChristopher CousinsCelina SureshErlina BurhanKa Lip ChewVictoria B DalayQingshu LuTutik KusmiatiVincent M BalanagShu Ling LeeRovina RuslamiYogesh PokharkarIrawaty DjaharuddinJani J R SugiriRholine S VetoChristine Sekaggya-WiltshireAnchalee AvihingsanonRohit SarinPadmasayee PapineniAndrew J NunnAngela M Crooknull nullPublished in: The New England journal of medicine (2023)
A strategy involving initial treatment with an 8-week bedaquiline-linezolid regimen was noninferior to standard treatment for tuberculosis with respect to clinical outcomes. The strategy was associated with a shorter total duration of treatment and with no evident safety concerns. (Funded by the Singapore National Medical Research Council and others; TRUNCATE-TB ClinicalTrials.gov number, NCT03474198.).