Downregulation of FHOD1 Inhibits Metastatic Potential in A549 Cells.

Marta Hałas-Wiśniewska Magdalena Izdebska Wioletta ZielińskaAlina Grzanka

Published in: Cancer management and research (2021)

Downregulation of FHOD1 induced reorganization of microfilament network followed by the reduction in the metastatic potential of the A549 cells, as well as their sensitization to selected compounds. The presented results and the analysis of clinical data indicate the possibility of transferring research from the basic level to in vivo models in the context of manipulation of ABPs as a new therapeutic target in oncology.

Keyphrases

induced apoptosis
squamous cell carcinoma
cell cycle arrest
small cell lung cancer
signaling pathway
cell proliferation
endoplasmic reticulum stress
electronic health record
cell death
human health
climate change
deep learning